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KMID : 1189420060190030055
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2006 Volume.19 No. 3 p.55 ~ p.59
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Determination of Glucan from Mycellium and Its Activity against Methicillin-Resistant Staphylococcus Aureus
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Kim Jeong-Hee
Na Seung-Young
Oh Seo-Jin
Jeong Seung-Il
Ju Young-Sung
Jung Young-Doo
Kim Hong-Jun
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Abstract
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Objective: This experimental study was performed to investigate the contents of glucan from mycellium and its activity against methicillin-resistant Staphylococcus(MRSA).
Methods: A gel permeation chromatography method was develped for the determination and isolation of glucan in mycellium. Their structures were elucidated using ¹H-NMR, ¹³C-NMR. Also, The antibacterial activity of the glucan against MRSA was estimathed by determining the minimum inhibitory concentration(MIC).
Results: The contents of glucan in mycellium was 766?0.19mg/g. Glucan exhibited activity against MRSA, with an MIC values of 4 to 9 mg/mL.
Conclusions: These findings suggested that glucan might be useful in controlling MRSA infections.
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KEYWORD
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glucan, mycellium, methicillin-resistant
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